Compile Data Set for Download or QSAR
maximum 50k data
Found 1470 of ic50 for Opioid receptor
having polymerids = 3138,3139,49000889 and
complexids = 50000141,50000896,50009013,50022928
LigandPNGBDBM50225205(CHEMBL540269)
Affinity DataIC50:  0.00300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataIC50:  0.00400nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017233(CHEMBL592 | LEVO-DROMORAN | LEVORPHANOL)
Affinity DataIC50:  0.00400nMAssay Description:50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50450653(CHEMBL2115493)
Affinity DataIC50:  0.00500nMAssay Description:Inhibitory activity against forskolin-stimulated cAMP production in chinese hamster ovary cells expressing Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataIC50:  0.00900nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50450653(CHEMBL2115493)
Affinity DataIC50:  0.0100nMAssay Description:Inhibitory activity against forskolin-stimulated cAMP production in chinese hamster ovary cells expressing Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50450656(CHEMBL2114469)
Affinity DataIC50:  0.0100nMAssay Description:Inhibitory activity against forskolin-stimulated cAMP production in chinese hamster ovary cells expressing Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001707(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)
Affinity DataIC50:  0.0130nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225845(CHEMBL293967)
Affinity DataIC50:  0.0150nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50228042(CHEMBL323548)
Affinity DataIC50:  0.0187nMAssay Description:The compound was tested for the ability to displace delta-receptor specific radioligand [3H]DPDPEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225204(CHEMBL606711)
Affinity DataIC50:  0.0200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  0.0270nMAssay Description:50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenateMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50450656(CHEMBL2114469)
Affinity DataIC50:  0.0400nMAssay Description:Binding affinity against rat Opioid receptor delta 1 expressed in CHO cells determined by competitive inhibition of 1 nM [3H]DPDPE.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  0.0500nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035145(1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...)
Affinity DataIC50:  0.0700nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035141(1'-(cyclohexylbutyl)-3H-spiro[2-benzofuran-1,4'-pi...)
Affinity DataIC50:  0.0700nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50071201((R)-2-[(R)-2-(2-{(R)-2-[(R)-2-Amino-3-(4-hydroxy-p...)
Affinity DataIC50:  0.0710nMAssay Description:Inhibitory activity against forskolin-stimulated cAMP production in chinese hamster ovary cells expressing Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225205(CHEMBL540269)
Affinity DataIC50:  0.0800nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225211(CHEMBL606767)
Affinity DataIC50:  0.0850nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50054124(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataIC50:  0.0890nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50054124(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataIC50:  0.0890nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50:  0.120nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035133(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50:  0.140nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001707(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)
Affinity DataIC50:  0.150nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225206(CHEMBL606643)
Affinity DataIC50:  0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326670(17-methoxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyc...)
Affinity DataIC50:  0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50061291((S)-2-{[(4R,7S,13S)-13-[(S)-2-Amino-3-(4-hydroxy-p...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of binding of radioligand [3H][p-Cl-phe]-DPDPE to Opioid receptor delta 1 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035144(1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035122(1'-(2-phenylpentyl)-3H-spiro[2-benzofuran-1,4'-pip...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225213(CHEMBL606820)
Affinity DataIC50:  0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027473(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Affinity DataIC50:  0.25nMAssay Description:Displacement of [3H]nalotrexone from rat-brain Opioid receptorsMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035129(1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50:  0.25nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035097(1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...)
Affinity DataIC50:  0.260nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035097(1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...)
Affinity DataIC50:  0.260nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035134(1'-(3-(cyclohexylthio)propyl)-3H-spiro[2-benzofura...)
Affinity DataIC50:  0.260nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035129(1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50:  0.270nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225848(CHEMBL53563)
Affinity DataIC50:  0.300nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataIC50:  0.300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013184(1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-1...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]dihydromorphine (DHM) from rat brain Opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225214(CHEMBL606769)
Affinity DataIC50:  0.300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035142(1-[1-(4-fluorophenyl)-1H-3-indolyl]-4-[6-fluorospi...)
Affinity DataIC50:  0.310nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  0.310nMAssay Description:Binding affinity was measured against Opioid receptor delta 1 using [3H]-p-Cl-DPDPE as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035135(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50:  0.340nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataIC50:  0.360nMAssay Description:Compound was tested for antagonistic activity against opioid receptor in mouse vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50037079(CHEMBL3355781)
Affinity DataIC50:  0.380nMAssay Description:Displacement of [3H][Ile5,6]deltorphin-2 from DOR in Wistar rat brain membranes by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035145(1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...)
Affinity DataIC50:  0.400nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50061292((S)-2-{[(4R,7S,13S)-13-[(S)-2-Amino-3-(4-hydroxy-p...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of binding of radioligand [3H][p-Cl-phe]-DPDPE to Opioid receptor delta 1 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50071201((R)-2-[(R)-2-(2-{(R)-2-[(R)-2-Amino-3-(4-hydroxy-p...)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity against rat Opioid receptor delta 1 expressed in CHO cells determined by competitive inhibition of 1 nM [3H]DPDPE.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224339(CHEMBL1744167)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224336(CHEMBL1744168)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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